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Product Description

Phleomycin is produced by Streptomyces verticullus and part of the structurally related group of bleomycin/phleomycin type antibiotics. The antibiotic is applied as a selective agent in transformation experiments with mammalian cells, plant cells and yeast. The cytotoxic action of the family of Bleomycin/Phleomycin related antibiotics results from their ability to cause fragmentation of DNA. The antibiotic binds to DNA through its amino-terminal peptide, and the activated complex generates free radicals that are responsible for scission of the DNA chain. Studies in vitro indicate that the antibiotic causes accumulation of the cells in the G2 phase of the cell cycle. Phelomycin should be stored between 2-8 ° C and is soluble in water.

Manufacturer: Duchefa Biochemie

SKU: P0187

CAS# 11006-33-0



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