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Ribavirin

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Product Description

Ribavirin is a synthetic nucleoside analogue structurally related to guanine. Ribavirine inhibits the replication of a wide range of RNA and DNA viruses. The antiviral mechanism of action of Ribavirin is not fully defined, but relates to alteration of cellular nucleotide pools and inhibition of viral mRNA synthesis. Intracellular phosphorylation of ribavirin into phosphate derivatives is mediated by host cell enzymes. Ribavirin monophosphates competitively inhibit cellular inosine-5-phosphate dehydrogenase and interfere with the synthesis of guanosine triphosphate (GTP) and thus nucleic acid synthesis in general. Ribavirin triphosphate also competitively inhibits the GTP dependent 5-capping of viral mRNA. Ribavirin should be stored at room temperature and is soluble in water.

Manufacturer: Duchefa Biochemie

SKU: R0182

CAS# 36791-04-5

M.F.:C8H12N4O5

M.W.:244.2

Link to MSDS

 

 

 


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