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Acyclovir

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Product Description

Acyclovir inhibits viral DNA synthesis by selective interaction with two distinct viral proteins Cellular uptake and initial phosphorylation are facilitated by thymidine kinase. Cellular enzymes convert the monosphophate to acyclovir triphosphate and compete for endogenous deoxyguanosine triphosphate (dGTP). Acyclovir triphosphate competitively inhibits viral DNA polymerases and, to a much smaller extent, cellular DNA polymerases Acyclovir triphosphate is also incorporated into viral DNA, where it acts as a chain terminator because of the lack of 3'-hydroxyl group. By a mechanism termed suicide inactivation, the terminated DNA template containing acyclovir binds the enzyme and leads to irreversible inactivation of the DNA polymerase Store at room temperature. Soluble in dilute aqueous solutions of alkali hydroxides and mineral acid.

Manufacturer: Duchefa Biochemie

SKU: A0183

CAS# 59277-89-3

M.F.:C8H11N5O3

M.W.:225.2

Link to MSDS

 

 

 


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